Why a universal antiretroviral regimen?

Citation: Flexner CW, Clayden P, Venter WDF. Why a universal antiretroviral regimen? Curr Opin HIV AIDS. 2017 Jul;12(4):315-317. doi: 10.1097/COH.0000000000000390. PMID: 28486340. PMCID: PMC5722220.

Access full article:

https://www.ncbi.nlm.nih.gov/pubmed/28486340

In 2015, with its "Treat all" recommendation, World Health Organization (WHO) removed all restrictions on eligibility for antiretroviral treatment (ART) among HIV positive people. WHO estimates that by the end of 2018, 20 million people worldwide will be receiving combination ART. An additional 15–17 million will be in need of ART but unable to access or afford it [1]. Most of the existing supply of antiretrovirals (ARVs) is provided through international agencies, such as PEPFAR and the Global Fund, or governments of low- and middle-income countries (LMICs), all of which face stable or shrinking health care budgets.

The economic challenges facing global provision of ARVs alone represent an overwhelming barrier to full treatment access. When combined with the logistical and implementation barriers, civil unrest, increasing ARV drug resistance worldwide, and continued issues with stigma in many parts of the world, it is hard to imagine how the treatment needs of all people with HIV can be met with existing programs and resources.

Categories

CRS
Topics

Clinical Trials

A5302:  BioBank for Surrogate Marker Research for TB...

Primary Objective To obtain sputum, serum, urine, and peripheral blood mononuclear cells (PBMCs) for central TB biorepository...

Read More

HPTN 069: A Phase II Randomized, Double-Blind, Study of the...

HPTN 069 is a phase II, four-arm, multisite, randomized, double-blinded trial. To assess the safety and tolerability of four...

Read More

A5314: Effect of LDMTX on Inflammation in HIV-infected...

A5314 is a phase II randomized, double-blind, placebo-controlled 36-week trial that will examine the safety and efficacy of...

Read More

HPTN083: A Phase 2b/3 Double Blind Safety and Efficacy Study...

HPTN 083 is a study being done to evaluate the efficacy of the long-acting injectable agent, cabotegravir (CAB LA), for...

Read More

A5279, Phase III Clinical Trial of Ultra-Short-Course...

This study will enroll HIV-infected people who do not have evidence of active TB but who are at high risk of developing active...

Read More