NWCS 408: Examining Longitudinal Cytokine Profiles in HIV-TB Co-infected Participants Examining Longitudinal Cytokine Profiles in HIV-TB Co-infected Participants to Study the Exit from Latent TB Infection and Death: A Supplemental Proposal for A5274
Study Location:
India
Topic:
Tuberculosis and HIV
IRB#:
IRB00091167
Enrollment:
Closed
Trial Period:
Ongoing
Using existing data from A5274 and data obtained from retrospectively testing available biospecimens, we propose the following specific aims:
Specific Aims:
- To determine whether the levels of a panel of proinflammatory cytokines and IL-32 at baseline are associated with progression to TB disease in advanced HIV-infected persons
- To determine whether baseline levels of cytokines associated with IL-1 and type 1 interferons are associated with early mortality
- To examine the association between longitudinal levels of the cytokines examined in aims 1 and 2 and development of TB or early mortality on ART