NWCS 408: Examining Longitudinal Cytokine Profiles in HIV-TB Co-infected Participants Examining Longitudinal Cytokine Profiles in HIV-TB Co-infected Participants to Study the Exit from Latent TB Infection and Death: A Supplemental Proposal for A5274

Study Location:

India

Topic:

Tuberculosis and HIV

IRB#:

IRB00091167

Enrollment:

Closed

Trial Period:

Ongoing

Using existing data from A5274 and data obtained from retrospectively testing available biospecimens, we propose the following specific aims:

Specific Aims:

  1. To determine whether the levels of a panel of proinflammatory cytokines and IL-32 at baseline are associated with progression to TB disease in advanced HIV-infected persons
  2. To determine whether baseline levels of cytokines associated with IL-1 and type 1 interferons are associated with early mortality  
  3. To examine the association between longitudinal levels of the cytokines examined in aims 1 and 2  and development of TB or early mortality on ART 

Categories

Location
Topic

Clinical Trials

A5329: Interferon –Free Therapy for Chronic Hepatitis C...

A5329 is a study for people who are infected with both HIV and the Hepatitis C virus (HCV) and have never taken Hepatitis C...

Read More

A5274: REMEMBER, Reducing Early Mortality and Early...

This study is being done in people who are starting HIV treatment and who live in areas where the TB infection rate is high. The...

Read More

A5314: Effect of LDMTX on Inflammation in HIV-infected...

A5314 is a phase II randomized, double-blind, placebo-controlled 36-week trial that will examine the safety and efficacy of...

Read More

NWCS 408: Examining Longitudinal Cytokine Profiles in HIV-TB...

Using existing data from A5274 and data obtained from retrospectively testing available biospecimens, we propose the following...

Read More

A5332: Randomized Trial to Prevent Vascular Events in HIV...

REPRIEVE (A5332) is a large double-blind, randomized, placebo-controlled study of pitavastatin or placebo for about 72 months....

Read More