NWCS 408: Examining Longitudinal Cytokine Profiles in HIV-TB Co-infected Participants Examining Longitudinal Cytokine Profiles in HIV-TB Co-infected Participants to Study the Exit from Latent TB Infection and Death: A Supplemental Proposal for A5274

Study Location:

India

Topic:

Tuberculosis and HIV

IRB#:

IRB00091167

Enrollment:

Closed

Trial Period:

Ongoing

Using existing data from A5274 and data obtained from retrospectively testing available biospecimens, we propose the following specific aims:

Specific Aims:

  1. To determine whether the levels of a panel of proinflammatory cytokines and IL-32 at baseline are associated with progression to TB disease in advanced HIV-infected persons
  2. To determine whether baseline levels of cytokines associated with IL-1 and type 1 interferons are associated with early mortality  
  3. To examine the association between longitudinal levels of the cytokines examined in aims 1 and 2  and development of TB or early mortality on ART 

Categories

Location
Topic

Clinical Trials

A5332: Randomized Trial to Prevent Vascular Events in HIV...

REPRIEVE (A5332) is a large double-blind, randomized, placebo-controlled study of pitavastatin or placebo for about 72 months....

Read More

HPTN 078: Enhancing Recruitment, Linkage to Care and...

The purpose of this study is to develop and assess the efficacy of an integrated strategy that includes feasible and scalable...

Read More

A5384: A Phase II, Randomized, Open-Label Trial of a...

Study Description A5384 is a trial for people who have or might have tuberculous meningitis (TBM). TBM is an infectious disease...

Read More

A5273: Multicenter Study of Options for Second-Line...

The study is being done with people who are taking their first anti-HIV drug regimen (including an Non-Nucleoside Reverse...

Read More

P2026: Pharmacokinetic Properties of Antiretroviral and...

IMPAACT P1026s, the predecessor of this study, was first approved in 2003. P1026s enrolled over 1000 pregnant/postpartum women,...

Read More