Identification of Biomarkers That Can Predict Progression from Latent Tuberculosis Infection to Active Tuberculosis Disease

Study Location:

India

Topic:

Tuberculosis

Enrollment:

Open

Trial Period:

Ongoing

Purpose: The C-TRIUMPH study has identified 20 household contacts (HHC), who have progressed to active TB from its HHCs cohort (Cohort B). Immunological profiling of TB antigen induced biosignatures, profiling of transcriptional and proteomic biosignatures should provide novel insights into the nature of the immune response that differentiates progressors to TB disease from non-progressors. We aim to measure the plasma biomarker profiles and profile microRNAs at baseline in HHC who progress versus those who do not. We will also measure the unstimulated, TB-antigen and mitogen stimulated cytokine and chemokine responses and unstimulated, TB-antigen and mitogen stimulated growth factors and other immune factors at baseline in HHC who progress versus those who do not to elucidate the differential immune profile between the 2 groups. Our study should provide us new insights into the nature of the immune signatures that differentiate progressors from non-progressor in this cohort.

Aims:
The major objectives of the study are to identify biomarkers that can accurately predict progression from latent TB infection to active TB disease,
To measure the plasma biomarker profiles at baseline in HHC who progress versus those who do not.
To profile microRNAs at baseline in HHC who progress versus those who do not.
To measure the unstimulated, TB-antigen and mitogen stimulated cytokine and chemokine responses at baseline in HHC who progress versus those who do not.
To measure the unstimulated, TB-antigen and mitogen stimulated growth factors and other immune factors at baseline in HHC who progress versus those who do not.

Adult, Pediatric, Household contacts

Categories

Location
Topic

Clinical Trials

A5314: Effect of LDMTX on Inflammation in HIV-infected...

A5314 is a phase II randomized, double-blind, placebo-controlled 36-week trial that will examine the safety and efficacy of...

Read More

A5128: Consent for Use of Stored Patient Specimens for...

The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other...

Read More

A5279, Phase III Clinical Trial of Ultra-Short-Course...

This study will enroll HIV-infected people who do not have evidence of active TB but who are at high risk of developing active...

Read More

P1108: A Phase I/II, Open-Label, Single Arm Study to...

This purpose of this study is to evaluate the pharmacokinetics (PK), safety, and tolerability of bedaquiline (BDQ) in...

Read More

HPTN083: A Phase 2b/3 Double Blind Safety and Efficacy Study...

HPTN 083 is a study being done to evaluate the efficacy of the long-acting injectable agent, cabotegravir (CAB LA), for...

Read More