Purpose: The C-TRIUMPH study has identified 20 household contacts (HHC), who have progressed to active TB from its HHCs cohort (Cohort B). Immunological profiling of TB antigen induced biosignatures, profiling of transcriptional and proteomic biosignatures should provide novel insights into the nature of the immune response that differentiates progressors to TB disease from non-progressors. We aim to measure the plasma biomarker profiles and profile microRNAs at baseline in HHC who progress versus those who do not. We will also measure the unstimulated, TB-antigen and mitogen stimulated cytokine and chemokine responses and unstimulated, TB-antigen and mitogen stimulated growth factors and other immune factors at baseline in HHC who progress versus those who do not to elucidate the differential immune profile between the 2 groups. Our study should provide us new insights into the nature of the immune signatures that differentiate progressors from non-progressor in this cohort.

Aims:
The major objectives of the study are to identify biomarkers that can accurately predict progression from latent TB infection to active TB disease,
To measure the plasma biomarker profiles at baseline in HHC who progress versus those who do not.
To profile microRNAs at baseline in HHC who progress versus those who do not.
To measure the unstimulated, TB-antigen and mitogen stimulated cytokine and chemokine responses at baseline in HHC who progress versus those who do not.
To measure the unstimulated, TB-antigen and mitogen stimulated growth factors and other immune factors at baseline in HHC who progress versus those who do not.

Adult, Pediatric, Household contacts